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KMID : 0390119930330010249
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Journal of Pusan Medical College
1993 Volume.33 No. 1 p.249 ~ p.264
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Detection of HPV DNA in SCC and Bowen's Disease by PCR
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Abstract
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In order to evaluate the role of human papillomavirus(HPV) in the development of premalignant lesions and cancers of the skin, 24 paraffin-embedded biopsy specimens obtained from 12 patients with squamous cell carcinoma(SCC) and 9 patients with
Bowen's
disease(BD) of the genital and hand/foot areas were analyzed by the polymerase chain reaction. HPV DNA sequences were detected in 16 specimens(66.7%): 4(66.7%) of 6 genital SCC, 3(50%) of 6 hand/foot SCC, 4(57.1%) of 7 genital BD and all 5(100%)
of
hand/foot BD. HPV DNA sequences, mostly HPV 16, were detected in 14(87.5%) of 16 specimens of positive amplified PCR products.
These results strongly suggest that specific HPV type, HPV-16, play an important role in the development of squamous cell carcinomas and Bowen's diseases at the genital and hand/foot areas.
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KEYWORD
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